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GLP-1RAs have attenuated beta cell dysfunction to varying degrees both in animal models [31] and in humans with type 2 diabetes [32]

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Nevertheless, patients using insulin or sulfonylureas may require dose adjustments when initiating potent incretin-based therapy because improved glycemia and reduced caloric intake can increase hypoglycemia risk when combined with therapies that independently lower glucose

The average cost for achieving a 1% reduction in body weight has been reported as lower with Tirzepatide, around $985, versus $1845 with Semaglutide

In the Phase 2b VESPER-1 trial, dosing was given as 28 weekly doses to characterize dose-response, with the intent to transition to monthly dosing in Phase 3