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Here authors report the cryo-EM structure of GLP-1R bound to an ago-allosteric modulator in complex with heterotrimeric Gs which offers insights into the molecular details of ago-allosterism.

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Alternatives to costly Wegovy and Saxenda will make such treatments more widely available worldwide

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Introduction A paradigm shift is currently sweeping through the food and beverage industry, catalyzed by a class of medications originally designed to treat diabetes: GLP-1 agonists (Glucagon-Like Peptide-1)