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2024 Apr 25;16(9):1271

Efficacy and safety of mazdutide in chinese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 2 trial

The medication mimics a natural human glucagon-like peptide (GLP-1) to slow the passing of food through the stomach

Sample sections were blocked in 5 % goat serum with 0.3 % Triton X-100 for 1 h at RT and then incubated overnight at 4 C with the following primary antibodies: mouse anti-GLP-1R (1:50, Santa Cruz, CA, USA), mouse anti-GLP-1(1:50, Santa Cruz, CA, USA), rabbit anti-Iba1 (1:500, Wako Chemicals, Tokyo, Japan), rabbit anti-GFAP (1:200, Cell Signalling, Boston, MA, USA), rabbit anti-NeuN (1:100, Proteintech, China), mouse anti-CGRP (1:100, Santa Cruz, CA, USA), and mouse anti-c-fos (1:100, Santa Cruz, CA, USA)

Arterial BP and ECG were recorded using a Power1401 interface and Spike2 software (Cambridge Electronic Design), and body temperature was maintained at 37.0 0.5 C

According to previous studies, patients with diabetes are four times more likely than people with no diabetes to experience severe Long COVID symptoms, but the exact mecahanisms remain unknown, he added