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The Effects of Tirzepatide on Cardiovascular Disease Due to tirzepatide's effect on the GLP-1R, one could expect similar protective benefits on cardiovascular health as other selective GLP-1R agonists [13]

Location: Found in various tissues, including pancreatic beta cells, the brain, heart, and gastrointestinal tract

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Absorption from the abdominal subcutaneous tissue tends to be slightly faster than from the thigh, though the difference is not clinically meaningful for a long-acting medication like tirzepatide

The process is slow at refrigerated temperatures but speeds up dramatically at room temperature, roughly doubling in rate for every 10 degree Celsius increase