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Transgenic AD models such as APP/PS1 mice, which overexpress mutant human amyloid precursor protein and presenilin-1, have also revealed mitochondrial fragmentation and respiratory deficits, reinforcing the hypothesis that impaired mitochondrial dynamics and mitophagy are mechanistically linked to AD pathology

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The brain performs a continuous calculation integrating hormonal signals from the gut, adipose tissue, and endocrine system GIP, GLP-1, glucagon, insulin, leptin, testosterone, estrogen to determine energy intake

This was highlighted in a recent study performed in a mouse model of obesity-induced T2DM, in which an 8-week exendin-4 treatment, starting 3 days post-stroke, improved neurological recovery by reversing T2DM-induced atrophy of parvalbumin-positive GABAergic interneurons, which play a key role in neuroplasticity [8]

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In short, you may feel overly full even uncomfortably so