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Introduction# Ecnoglutide (XW003, Sciwind Biosciences) and semaglutide (Novo Nordisk) are both GLP-1 receptor agonists for obesity and type 2 diabetes, but they differ fundamentally in their signaling pharmacology

Tirzepatide is a more comprehensive and sustainable option, though it costs more

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Consequently, both insulin and RF-409 increased IR autophosphorylation and pAKT in whole-liver lysates, with RF-409 inducing higher activation levels (Fig