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Marso SP, et al

These actions improve glucose control in type 2 diabetes patients who have weak GLP-1 response

Phase 3 TRIUMPH trials are testing 9 mg and 12 mg as maintenance doses, along with a 4 mg maintenance dose arm for patients who respond adequately at lower doses

In June 2021, the FDA approved its use for chronic weight management in adults who are overweight or obese A 2022 study finding once patients go off the medication the average weight gain rebound is about 2/3 of the total weight lost

Moreover, sleep deprivation has been shown to directly affect glucose metabolism

Step 6: 72-hour fast A 72-hour fast is recommended in severe cases of PGBH in patients for whom dietary modification and the additional pharmacotherapy outlined in step 5 have failed