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c , Change in body weight of DIO mice treated with once-daily s.c

Potential future developments include novel delivery mechanisms, multi-receptor agonists, and a broader range of therapeutic uses for the treatment of metabolic disorders and their consequences

However, we performed sensitivity analyses by excluding one study at a time and did not find a single study that affected the final results

Our topic modeling pipeline identified a total of 168 discussion topics (Supplementary Data 1), with most discussions focusing on individual experiences with GLP-1 RA for weight loss with respect to medication efficacy, comparison to other treatments, impact on appetite, and side effects

In a Phase II readout released in August 2022, the pharma touted a 15.6% drop in body weight in patients taking CagriSema, versus 5.1% in comparators on semaglutide alone and 8.1% in patients treated with only cagrilintide

To address them, the field is rapidly developing new frameworks, as seen in recent perspective papers we published, discussing "clock-to-clock" analysis and using diseases as a testbed for longevity interventions
