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A study published in the Endocrine Society journals documented nodule formation with once-weekly exenatide, noting that nodules were typically 0.5 to 0.75 centimeters in diameter and tended to resolve on their own over time

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As a GLP-1 receptor agonist, it works by mimicking the natural incretin hormone GLP-1 to increase insulin secretion in a glucose-dependent manner, suppress glucagon release, slow gastric emptying by approximately 35%, and reduce appetite through central nervous system signaling

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