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GLP-1 medications work by mimicking natural incretin hormones to improve blood glucose control and reduce appetite Common side effects are gastrointestinal (nausea, vomiting, diarrhoea) rather than fluid retention Unlike thiazolidinediones, GLP-1 agonists are not associated with oedema as a recognised adverse effect Any unexplained swelling whilst taking GLP-1 medications requires medical assessment to exclude other causes Dehydration from gastrointestinal side effects is more common than fluid retention with GLP-1 therapy Table of Contents What Are GLP-1 Medications and How Do They Work

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While once-weekly injectables offer a more convenient alternative to daily administration, the requirement for subcutaneous injection remains a barrier for some patients