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Eligible participants had a body mass index of 30 or greater, or 27 or greater with at least one obesity-related complication

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Patients with disc-at-risk anatomy display these characteristic features: Small optic disc diameter (less than 1.2 millimeters) Minimal or absent physiological cup (cup-to-disc ratio of 0.2 or less) Crowded arrangement of approximately 1.2 million nerve fibers Limited space for axons to exit through the lamina cribrosa Increased susceptibility to compartment syndrome effects The pathophysiological mechanism underlying NAION involves a cascade of events beginning with initial hypoperfusion of the optic nerve head

It can be an effective rescue medication for severe diarrhea episodes, but it should not be used routinely during retatrutide treatment