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DRUG-DRUG INTERACTIONS BETWEEN GLP-1RAS AND OTHER DRUGS GLP-1RAs can affect concurrently administered drugs' pharmacokinetics (PK), primarily through their effects on gastrointestinal motility

Xu Q, et al

For constipation, increasing dietary fiber, fluid intake, and physical activity typically provides relief

That said, its worth knowing that certain oral GLP-1 medications, like Rybelsus (oral semaglutide), need to be taken on an empty stomach with just a small sip of water, at least 30 minutes before eating or drinking anything else

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61 The crystal structure of GLP-1 showed a continuous -helix from Thr 13 to Val 33 with a kink around Gly 22