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Tirzepatide can cause stronger digestive side effects at higher doses

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Celiac disease affects approximately 1 in 100 people worldwide and creates unique challenges for weight management because intestinal damage reduces nutrient absorption and increases inflammation

Body weight in the semaglutide group decreased by an estimated 6.8 kg more than placebo, confirming the expected weight loss effect, but the bone changes occurred in parallel rather than being fully explained by mechanical unloading from weight loss alone