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Common side effects of sitagliptin include: Diarrhea Headache Nausea Sore throat Stuffy or runny nose Swelling of hands or legs Upper respiratory infection Serious sitagliptin side effects include: Allergic reactions (hives, difficulty breathing or swelling of the lips, face, tongue or throat) Heart failure (rapid increase in weight, shortness of breath or swelling of the feet) Hypoglycemia (low blood sugar) Necrotizing pancreatitis (a complication of acute pancreatitis that causes tissue death) Acute pancreatitis (inflammation in the pancreas, causing abdominal pain) Severe joint pain Severe skin reaction (rash, blistering or peeling, burning eyes or facial swelling) Increased blood glucose, pancreatitis, pancreatic cancer and gastrointestinal disorders (vomiting, diarrhea and nausea) were the most commonly reported side effects of Januvia and Janumet to the FDAs Adverse Event Reporting System (FAERS)

For the study, researchers evaluated the dermatologic and injection-site reaction safety of GLP-1RAs via a meta-analysis of randomised controlled trials (RCTs) and a disproportionality analysis of data from the United States Food and Drug Administration Adverse Event Reporting System (FAERS)

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But Garg has had some scary experiences with his own patients who overcompensated and began taking even less insulin than he advised because they were scared of getting hypoglycemia

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Switching from semaglutide to tirzepatide can help some individuals achieve additional weight loss, better appetite control, and improved metabolic health