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[73] While this interaction may sometimes be therapeutically beneficial in carefully managed situations, it also increases the risk of excessive sedation, impaired cognitive function, and potentially dangerous activities such as driving

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22 , 23 , 24 In terms of spatial distribution, a higher concentration of M2-TAMs within the tumors core is closely tied to the resistance observed in NSCLC patients to PD-1/PD-L1 checkpoint inhibitors