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Although NLRC4 has not shown to be involved in PD pathogenesis, it has been implicated in neuroinflammation in the context of acute brain injury (Denes et al., 2015)

Instead, it is being studied in clinical trials for obesity and overweight with weight-related conditions, type 2 diabetes, knee osteoarthritis pain, moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal outcomes, and metabolic dysfunction-associated steatotic liver disease

[2] [4] However, clinical experience in patients on dialysis or with advanced CKD and obesity (without diabetes) is more limited