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Description
Glucagon-like peptide-1 (GLP-1)receptor agonists (GLP-1RAs) were first introduced for the treatment of type 2 diabetes (T2D) in 2005

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Absolute and relative loss of total lean body mass, assessed via DXA scan, is often used as surrogate endpoint for measuring the impact on muscle mass, despite its obvious limitations, e.g., including the weight of organs, bones, tissue and fluids in addition to muscle

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For those who want to go deeper: JAMA Psychiatry (2025):- GLP-1 RAs & Mental Health Meta-Analysis: JAMA Psychiatry (2025):- Semaglutide & Alcohol Use Disorder RCT: eClinicalMedicine / The Lancet (2024):- 12-Month Neurological & Psychiatric Outcomes of Semaglutide: APA Monitor (2025):- Mental Health Effects of GLP-1 Drugs (accessible overview):
