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Exendin-4 significantly increased insulin level and phosphorylation of insulin receptor substrate 1 (IRS-1) in rat hippocampus, and could not change the status of tau phosphorylation without insulin in HT22 neurons, suggesting that insulin is required in reduction of tau hyperphosphorylation by GLP-1R agonists (154)

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Given that EtO is a known human carcinogen, the study reinforces the need for updated occupational exposure monitoring and more vigorous enforcement in high-risk industries

Because modified levels of PYY are correlated with various metabolic disorders that also impact bone mass, PYY may potentially exert an influence on bone homeostasis