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Non-genomic mechanisms activate during the application of prednisone dosages above 100 mg and reach the greatest effects around 250 to 500 mg [10]

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GLP-1 induced activation of PKA increases Pdx1 expression and translocation of Pdx1 to the nucleus, where Pdx1 binds to the insulin promoter to initiate insulin expression and synthesis (Figure 5) [490,524]

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