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\n\nHowever, the technological frontier, validated by historic FDA and EMA approvals, has introduced a total paradigm shift with the arrival of gliflozins and non-steroidal mineralocorticoid antagonists

It debuted in the United States in 2017 as an injectable diabetes drug called Ozempic, manufactured by Novo Nordisk

Animal studies demonstrated dose-dependent and treatment-duration-dependent increases in thyroid C-cell tumours in rodents treated with GLP-1 receptor agonists

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We included costs of lost earnings due to absenteeism (acute and chronic), workforce dropout due to CVD or ESKD, and loss of future earnings from premature mortality (death before retirement age, which was set at 67 years)