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Large-scale, placebo-controlled randomized clinical trials specifically designed for psychiatric populations are critically needed to determine the efficacy, optimal dosing, duration, and long-term safety of GLP-1 RAs in treating mood symptoms [101]

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Subsequent evaluations of the SUSTAIN and PIONEER trials have reaffirmed semaglutide's efficacy in diminishing both relative and absolute risks for significant adverse cardiovascular events in comparison to control therapies (Husain et al