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Clinical Trial Evidence and Weight Loss Outcomes A Phase 2 RCT (NEJM 2023) reported approximately 24% mean body weight reduction at 48 weeks with the 12 mg dose
[DOI] [PMC free article] [PubMed] [Google Scholar] 396.Zhang CY, et al
The Blundell study quantified this effect: a 24 percent reduction in total daily energy intake and a 35 percent reduction in ad libitum lunch intake
Evidence-Based Alternative: Domperidone (peripheral action) for nausea
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