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Given the vast number of incretin-based medications under development, mainly aiming at higher efficacy in body weight reduction, one may overlook that adherence to, and persistence of, therapy with GLP-1RAs in real-world studies is relatively low (18, 126)

3.1%), with obvious implications for patient burden and healthcare system costs [45]

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And as further data from Gallup shows, more and more Americans are trying these drugs, with the survey finding that more than 12 percent of adults reported taking them in the second and third quarters of 2025, up from less than 6 percent in early 2024

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