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doi: 10.1007/s11154-021-09669-7 8 GriecoMGiorgiAGentileMCdErmeMMoranoSMarasBet al

Keywords: type 2 diabetes, obesity, insulin, glucagon, GLP-1, GLP-1R, incretin, metabolism Introduction Maintaining metabolic homeostasis is essential in all living organisms, as it provides energy in the form of adenosine trisphosphate (ATP) required for cellular processes to proceed

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Chronic low-grade inflammation associated with obesity and insulin resistance may contribute to fatigue, though the direct relationship between reduced inflammation and energy levels requires further research

The European Cardiovascular Health Plan Roadmap from the European Alliance was published earlier in 2025 and calls for comprehensive approaches to incorporate the recognition of obesity as a trigger for cardiovascular disease

When these receptors are stimulated, they activate pathways involved in cell growth, repair, and defense against damage