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The biggest potential concern about GLP-1 microdosing is that a person may not be taking enough of a medication to treat the condition for which it has been prescribed

There is intriguing but conflictual support for the use of DHEA (in addition to glucocorticoids and mineralocorticoids) in treating patients with Addisons disease or hypopituitarism

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Who Should Exercise Caution Research protocols should be designed with extra caution or retatrutide may be contraindicated in subjects with: Pre-existing tachycardia or arrhythmias (e.g., atrial fibrillation, supraventricular tachycardia) Thyroid conditions, particularly hyperthyroidism (which already elevates heart rate) Use of stimulant compounds (caffeine stacking, sympathomimetic amines) History of heart failure or reduced ejection fraction Concurrent use of other agents known to elevate heart rate Research Note: Retatrutide is not approved for human use
