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In a phase 2 randomised controlled trial published in the New England Journal of Medicine (Jastreboff et al., 2023), participants receiving the highest doses of retatrutide achieved a mean weight reduction of approximately 1724% of body weight over 48 weeks, depending on dose

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This reduction was primarily driven by a decrease in hospitalization rates [43]

Designed to work together

and Davies, M., 2023

Proper medication timing, regular thyroid function monitoring, and dose adjustments during weight loss are essential for safe concurrent use under medical supervision