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GLP-1RAs reduce circulating inflammatory mediators, suppress NLRP3 inflammasome activity, and lower oxidized LDL, thereby limiting the initiation of vascular injury

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The trial design is shown in Figure 1

The 9mg addition may eventually prove to be the ideal maintenance dose, capturing most of the 12mg efficacy with fewer side effects than either the 8mg or 12mg tiers

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Contact your GP if tiredness persists beyond 46 weeks, significantly impairs daily activities, is accompanied by frequent hypoglycaemia, signs of dehydration, unexplained weight loss, mood changes, or symptoms suggesting sleep apnoea such as excessive daytime sleepiness