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FDA-approved semaglutide showed outstanding results in clinical trials, with up to 40% of participants losing 20% of their body weight

People should therefore not rely on these injections to promote fat loss

doi: 10.1186/s12954-024-00929-8

GLP-1, GIP & Inflammation: What These Medications Really Do and What They Dont Joshua Silva, MD Dec 5, 2025 7 min read Updated: Jan 27 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD Quick Answer GLP-1 and GLP-1/GIP medications (such as semaglutide and tirzepatide ) can lower metabolic inflammation by improving insulin resistance, reducing visceral fat, and lowering inflammatory biomarkers such as C-reactive protein (CRP) ., They can also improve cardiometabolic risk markers (e.g., blood pressure) and, for tirzepatide, can improve atherogenic lipoprotein measures including apoB and triglyceride-rich lipoproteins in clinical research settings., They do not treat autoimmune diseases or fibromyalgia directly

The safety monitoring committees, whose entire job is to flag concerning side effect patterns, did not raise urinary tract infections as a signal worth investigating further