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The beneficial effects of GLP-1 receptor activation on glycemia occur through several mechanisms: GLP-1 stimulates glucose-dependent insulin secretion from pancreatic -cells, suppresses inappropriately elevated glucagon secretion from pancreatic -cells, delays gastric emptying, and induces satiety via a direct action in the central nervous system

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However, when SCFAs are given to GPR43 knockout mice, GLP-1 secretion cannot be stimulated (39)

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These findings indicate that GLP-1RAs have anti-adhesive and anti-thrombotic properties in the endothelium that may delay the development of atherosclerosis [110]