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Pfizers move to acquire Metsera followed recent setbacks in Pfizers in-house drug candidates for obesity

This rise in cAMP activates both PKA and exchange proteins directly activated by cAMP (Epac), which collectively augment insulin transcription, secretion, -cell proliferation, and survivalmechanisms essential for glucose homeostasis and diabetes control [34, 35]

Youve likely heard about Tirzepatide (Mounjaro, Zepbound) as well

And it should not be marketed as a natural substitute for medications like semaglutide or tirzepatide

doi: 10.1038/ijo.2013.149 91 le RouxCWAstrupAFujiokaKGreenwayFLauDCWVan GaalLet al

[Source: Fierce Pharma ] January 2025 The FDA fast-tracked tirzepatide for cardiovascular risk reduction in obesity patients, following landmark trial results showing significant benefit beyond weight loss