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In PWS, central hypothyroidism (CH) is the most common thyroid function abnormality, with a prevalence ranging from 2% to 72.2% globally ( Supplementary Table 1 )

(SURMOUNT-1) Jastreboff AM, Kaplan LM, Fras JP, et al

So in short, the prevailing view in psychiatry, broadly, is that mental illnesses are a result of an abnormal function in the brain cells

That said, semaglutide still produces clinically meaningful, life-improving weight loss for the majority of patients

Adams, J

What to Expect: Onset, Duration, and Personalization with PlexusDx Most patients experience noticeable appetite reduction within 24 hours of their first sublingual semaglutide dose, with progressive appetite suppression deepening over the first 23 weeks