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PGBH should initially be treated with a high-protein, high-fiber, low-carbohydrate diet and then, if hypoglycemia persists, by medication (initially acarbose, then a calcium channel blocker and octreotide or diazoxide or both)

Clinical development is now in the Phase 3 TRIUMPH registrational program a multi-trial registrational basket spanning obesity, obstructive sleep apnoea, knee osteoarthritis, type-2 diabetes, MASLD/NASH, and chronic kidney disease across more than 5,800 participants

Patients participating in these 3 trials had a mean age of 40 years, a mean duration of diabetes of 17 years, and a mean body mass index of 25.9 kg/m2

Hormonal shifts during perimenopause and menopauseparticularly the drop in estrogen, progesterone, and DHEAcreate a cascade of changes in the body: Slower metabolism (especially after age 40) Increased insulin resistance Visceral fat accumulation (around the belly and midsection) Disrupted sleep and cortisol imbalance Loss of lean muscle mass This isnt just about appearance

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