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Hepatic Steatosis : Recently, a sub-study of the phase 3 clinical trial SURPASS-3 showed that, among patients receiving metformin and/or SGLT2 inhibitors, the addition of tirzepatide (10 or 15 mg) as compared to insulin degludec was able to significantly reduce hepatic fat content (evaluated by magnetic resonance) after 52 weeks of treatment

Why this matters: HS is not only a skin-deep condition

As adoption of GLP-1s continues to become more and more mainstream, this trend will only intensify

This creates a multiplicative rather than additive effect on appetite suppression

Sometimes its just a macrophage being a macrophage