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Cell Rep 2021;37:110104.ArticlePubMed 132

They enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release from alpha cells, and slow gastric emptying

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Farxiga Heart Failure Dosing : Standard dose: 10mg once daily Used regardless of diabetes status Continue unless eGFR falls below 25 mL/min/1.73m Monitor kidney function and volume status Jardiance Heart Failure Dosing : Standard dose: 10mg once daily Used in patients with or without diabetes Continue unless eGFR falls below 20 mL/min/1.73m Regular monitoring of kidney function is required Both medications should be continued during heart failure hospitalizations unless acute kidney injury develops

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