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In 2019, the REWIND trial found that in the 9901 patients with T2DM with and without previous CVD randomly assigned to a once-weekly 1.5 mg dulaglutide injection or placebo (median follow-up 5.4 years), three-point MACE occurred in 594 patients receiving dulaglutide (12.0%) and in 663 patients (13.4%) in the placebo group, which included a significant decrease in the rate of non-fatal stroke (Gerstein et al

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Open-field test Locomotor activity was evaluated using an open-field test

Postprandial GLP-1 binds to GLP-1R expressed in the vagal afferent neurons, inducing firing of cultured vagal afferent neurons [53,54]

The details of primer sequences used are: Rat GLP-1R forward

GLP-1 is Glucagon-Like Peptide-1 (and yes, there is a 2)