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Nonetheless, despite these encouraging results, further study, including clinical trials, is required to determine the efficacy, tolerability, and underlying mechanisms of DPP4-is in the treatment of neuropathic pain

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Wang L, Wang N, Zhang W, Cheng X, Yan Z, Shao G, et al

Keywords: type 2 diabetes, obesity, glucagon-like peptide-1 receptor agonists, gastrointestinal adverse events, guidelines 1

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Lifestyle interventions (including diet, exercise and behavioural changes) are the cornerstone of obesity management with diverse benefits, but even the most intensive lifestyle interventions result in up to 10% mean weight loss (WL) and weight maintenance remains a challenge, as 80% of WL is expected to be regained over the next 5 years [4, 5]