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The main use being investigated is chronic weight management in adults with obesity or overweight

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While these antiinflammatory effects have not been attributed to GLP-1 action in specific organs or cell types, the kidney GLP-1R has been localized primarily to vascular smooth muscle cells within renal arteries and arterioles using either 125 I-labeled exendin-4, a validated antiGLP-1R antibody, or in situ hybridization (71, 72)