retatrutide phase 3 #obesity #osteoarthritis #clinicaltrials #medicine #research Today, we shared new data

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In the largest pharmacogenomics GWAS of GLP-1 medications to date (15,237 participants, replicated in the All of Us cohort), researchers identified a missense variant in GLP1R the gene encoding the very receptor that semaglutide and tirzepatide bind that significantly predicts how much weight a person loses on treatment

Methods Blood was drawn from 24 subjects (14 male, 10 female, age: 50.77.36years, BMI: 26.643.38kg/m2, GHbA1c: 7.000.74%) with drug-nave T2D at 0 and 120min following a standard mixed meal for the measurements of active GLP-1, NO and NOS

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