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76 Clinical studies have shown that GLP-1 and its receptor agonist exenatide can improve human bronchial hyperresponsiveness (BHR) by inducing pulmonary vasorelaxation and phosphatidylcholine secretion through activation of the cAMP-PKA-dependent pathway, 77 and by stimulating the secretion of phosphatidylcholine (a major component of surfactant) through cAMP-dependent PKA and cAMP-dependent PKC, thereby improving lung function

GLP-1 Receptor Agonists (GLP-1RAs) Mechanism: Mimic GLP-1 via direct receptor stimulation at supraphysiological levels

Nature,286-288 11.Abdullah Bin Ahmed I

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