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Lipid conjugation has been employed in the development of long-acting analogues such as insulin detemir, insulin degludec, liraglutide, semaglutide, and tirzepatide, allowing for administration either once daily (as seen with detemir, degludec, and liraglutide) or once weekly (as with semaglutide and tirzepatide)

4.9%), exenatide (Byetta

Clegg LE, Penland RC, Bachina S et al (2019) Effects of exenatide and open-label SGLT2 inhibitor treatment, given in parallel or sequentially, on mortality and cardiovascular and renal outcomes in type 2 diabetes: insights from the EXSCEL trial

The psychological burden of managing a long-term condition, concerns about complications, and the impact of symptoms on quality of life can all affect mental health

For a full list of warnings and side effects, please see the Patient Information Leaflet

A phase 2 trial published in the New England Journal of Medicine showed average weight loss of over 24% at 48 weeks, and the first phase 3 results in December 2025 suggested that average weight loss could be around 28 to 29%