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Fact: While letrozole makes weight loss more challenging due to hormonal changes, GLP-1 medications have shown promise in helping individuals overcome these metabolic hurdles

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Funding This work was supported by the National Natural Science Foundation of China [grant numbers 82470907, 82270880, and 82400944] Data availability All data supporting the findings of this study are available in the manuscript and supplementary materials

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20mg Multi-dose vial for clinic administration Retatrutide activates three hormone receptor pathways: GIP, GLP-1, and glucagon