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[DOI] [PubMed] [Google Scholar] 92.Fala L

It is important to contextualise these findings

The primary endpoint was percentage change in body weight

Regarding gonadal effects, treatment with GLP1/E, GLP1/GIP, and metformin did not alter ovarian or uterus weights, nor did they change circulating LH levels in this hyperandrogenic model of PCOS (Suppl

FDA-approved alternatives like semaglutide (10-15% loss), tirzepatide (15-22% loss), and CagriSema (15-25% loss) offer comparable or superior results with proven long-term safety profiles, cardiovascular benefits rather than risks, and legal medical oversight

Researchers analyzed data from the U.S