does glp 1 cause weight loss The Benefits of GLP-1 Therapy: Beyond GLP-1 Medications Clinic Near Me

For type 2 diabetes management , NICE guideline NG28 recommends considering GLP-1 receptor agonists when: Triple therapy with metformin and two other oral medications is ineffective, not tolerated or contraindicated The patient has a body mass index (BMI) of 35 kg/m or higher (with lower thresholds for people from certain ethnic backgrounds), or lower BMI with specific clinical circumstances where weight loss would benefit other obesity-related comorbidities Insulin would have significant occupational implications GLP-1 therapy should only be continued beyond six months if there has been a beneficial metabolic response, defined as a reduction in HbA1c of at least 11 mmol/mol (1.0 percentage point) and weight loss of at least 3% of initial body weight

Additionally, GI motility assessments with microbiome profiling are warranted to investigate the relationship of GLP-1-based therapy, delayed transit, and bacterial overgrowth, which will significantly enhance clinical management and prevention strategies

Adipokines, such as adiponectin and omentin, are also involved, with decreased levels contributing to metabolic dysfunction

Lamari, Y., Boissard, C., Moukhtar, M

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Mridha AR, Wree A, Robertson AA, et al