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As in previous experiments, intervention with an effective dose of metformin had minimal effects on the metabolic profile (Fig

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[DOI] [PubMed] [Google Scholar] 6.Donini L.M., Busetto L., Bischoff S.C., Cederholm T., Ballesteros-Pomar M.D., Batsis J.A., et al

And as long as it's continued to completion, I don't think efficacy is really a question at this point either. However, lower dosing often means a longer treatment course

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In chronic PD mice, the triple receptor agonist HM15211 protected against dopaminergic neuronal death, decreased -synuclein accumulation, and prevented nigrostriatal neurodegeneration by mitigating the inflammatory response and lipid peroxidation [124, 125]