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Effects of semaglutide on albuminuria and kidney function in people with overweight or obesity with or without type 2 diabetes: exploratory analysis from the STEP 1, 2, and 3 trials

Pratley RE, Kang J, Trautmann ME, Hompesch M, Han O, Stewart J, et al

Rapid weight loss from taking GLP-1 medications like Ozempic and Wegovy can result in a decrease in muscle mass, lessen bone density, and lower your resting metabolic rate

Conversely, some individuals who initially tolerated high doses find that after substantial weight loss, lower doses provide adequate maintenance with fewer side effects

In rats, administration of GLP-1R agonists into the hippocampus further prevented impairment of spatial learning and memory induced by central administration of amyloid (A), a protein considered to play a causative role in impairment of learning and memory in Alzheimer disease [832,833]

When using bismuth subsalicylate with semaglutide, maintain a 2-hour spacing between medications to avoid potential absorption interactions. 4