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This lack of research raises concerns because non-diabetic patients face different risks and benefits than diabetic patients

Quick Answer: Feeling cold on GLP-1 medications results from physiological changes during weight loss, including reduced insulating fat tissue, decreased caloric intake lowering heat production, and metabolic adaptations that make the body more energy-efficient

These non-incretin metabolic peptides frequently exert effects on peripheral tissues such as skeletal muscle, adipose tissue, liver, and vasculature, and often engage receptors distinct from those targeted by current therapies

That shortens the digestion period

Consider prophylactic famotidine if symptoms appeared at the lower dose

or stimulated with IFN-gamma increase the catabolism of tryptophan via the indoleamine 2,3-deoxygenate (IDO1) pathway, resulting in quinolinate production