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Weight management: As an oral weight loss medication, it supports gradual, steady weight reduction alongside a balanced diet and exercise

Meet our doctors Last reviewed: 02 Jun 2026 Sources BMJ (2021)

The medication does not permanently rewire hunger signals

Most patients report minimal hunger at these levels because semaglutide suppresses appetite hormones and slows stomach emptying

The potential benefits of adding semaglutide after gastric sleeve surgery primarily address inadequate weight loss or weight regain, which affects approximately 15-30% of bariatric surgery patients

Still, we can speculate what might be happening based on our understanding of how the body responds to weight loss, including altered metabolism, reduced blood flow to extremities, decreased food-induced heat production, and loss of insulating body fat