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Multiple 20242026 systematic reviews and meta-analyses have compiled the early-phase data (PMID 39318607, PMID 40291085, PMID 40685589, PMID 40728138, PMID 41785010)
In 1973, Dupre et al
A study of patients with mast cell activation syndrome found that they were about 3 times more likely to have restless leg syndrome than a control group.[ref] Related article: Histamine receptors, histamine intolerance Inflammation and RLS/PLMD: Some studies show higher inflammatory cytokines in people with RLS and/or PLMD
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