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The SURMOUNT-1 study was a placebo-controlled 72-week trial in obese subjects that randomized 2,539 participants without diabetes into four equally large study arms with placebo or one of the three tirzepatide doses (5, 10, or 15 mg once weekly)

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STEP-UP trial success : At an escalated 7.2 mg dose, participants in clinical studies achieved 21%25% weight loss, demonstrating performance similar to Mounjaros in head-to-head evaluations

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