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Adapted from DeFronzo R The imbalance between alpha and beta cells is a novel mechanism implicated in the pathogenesis of Type 2 DM described in the last few years

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Certainly, the apparent advantage of tirzepatide, a dual incretin agonist, over GLP-1RA will spark renewed interest in the therapeutic potential of GIP in type 2 diabetes, obesity and related co-morbidities.

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